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Nuzzo, Ralph G. Nuzzo, Ralph G. Murphy, Catherine J. Rogers, John A. Sweedler, Jonathan V. Le, An-Phong 2012-02-01T00:46:01Z 2012-02-01T00:46:01Z 2014-02-01T11:00:25Z 2011-12 2012-02-01T00:46:01Z 2011-12 Surface plasmon resonances (SPR) have been exploited through various means for the realization of label-free, surface-sensitive chemical analysis and imaging, all of which rely on the interactions between the local environment and the evanescent electric fields generated by the surface plasmons at the metal-dielectric interface. Plasmonic crystals are a versatile platform for the tunable coupling of light into surface plasmon modes, and soft nanoimprint lithography represents a class of fabrication techniques capable of inexpensive, high fidelity replication of nanoscale features over large areas; these methods are well-matched for surface-enhanced sensing applications whose performance depends strongly on these fabrication characteristics. The work presented in this dissertation focused on the development of new surface-enhanced Raman spectroscopy and surface plasmon resonance imaging modalities based on this nanostructured plasmonic crystal platform. Nanostructured plasmonic crystals were patterned onto the tips of silica optical fibers using a soft embossing method for use as single-fiber SERS optrodes, and enhanced Raman scattering was observed for benzenethiol monolayers adsorbed onto the structured fiber tip as well as for Rhodamine 6G dissolved in aqueous solution. The inherent versatility of this plasmonic platform for SERS-based sensing was demonstrated through the effective Raman enhancements obtained in markedly different refractive index environments. Nanoimprinted plasmonic crystals were also adapted for reflection imaging studies of thin films deposited onto the metal surface. Normalized contrast metrics were developed based on reflection images of polyelectrolyte layer-by-layer assemblies acquired using bandpass filters to restrict the accessible wavelength ranges and quantitatively calibrated to the surface film thickness. As a model system, Aplysia pedal neurons were cultured on the plasmonic crystal surface, and the thicknesses of neuronal processes were quantitated using the calibrations derived for this reflection imaging protocol using common laboratory equipment: a reflection microscope, commercially available bandpass filters, and a digital camera. The imaging-based measurements of neuronal process thickness were verified independently using atomic force microscopy with excellent agreement between the two methods. The applications explored in this dissertation demonstrate the broader utility of nanoimprinted plasmonic crystals for chemical sensing and imaging. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-08-04T13:27:15Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 2 Le_An-Phong.doc: 44377088 bytes, checksum: 7c64e998f75c18a9d59d1285dc6283cf (MD5) Le_An-Phong.pdf: 4521764 bytes, checksum: 869e3b68ef7294aa7c06b8268ef38139 (MD5) Made available in DSpace on 2012-02-01T00:46:01Z (GMT). No. of bitstreams: 3 Le_An-Phong.pdf: 4521764 bytes, checksum: 869e3b68ef7294aa7c06b8268ef38139 (MD5) license.txt: 4051 bytes, checksum: ddea1a0d8b49203a6c1893f7991efd40 (MD5) Le_An-Phong.doc: 44377088 bytes, checksum: 7c64e998f75c18a9d59d1285dc6283cf (MD5) Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2012-02-01T00:50:21Z Item is restricted until 2014-02-01T00:50:07Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:25Z Item was in collections: Dissertations and Theses - Chemistry (ID: 676) Graduate Theses and Dissertations at Illinois (ID: 204) No. of bitstreams: 4 Le_An-Phong.pdf: 4521764 bytes, checksum: 869e3b68ef7294aa7c06b8268ef38139 (MD5) license.txt: 4051 bytes, checksum: ddea1a0d8b49203a6c1893f7991efd40 (MD5) Le_An-Phong.doc: 44377088 bytes, checksum: 7c64e998f75c18a9d59d1285dc6283cf (MD5) Le_An-Phong.pdf.txt: 257365 bytes, checksum: a5d3fc29a55e191a468b438ff1342ffb (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:25Z http://hdl.handle.net/2142/29428 en Copyright 2011 An-Phong Le Surface Plasmon Resonance Surface-enhanced Raman (SER) cell imaging thin film quantitative reflection imaging Surface plasmon resonance imaging (SPRi) Analytical applications of nanostructured plasmonic crystals Chemistry 1413 Chemistry 0335 University of Illinois at Urbana-Champaign Dissertation Ph.D. PHD:Chemistry -UIUC 10KS0335PHD