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Pack, Daniel W. Xia, Yujie 2012-02-01T00:54:27Z 2014-02-01T11:00:22Z 2011-12 2012-02-01T00:54:27Z 2011-12 Biodegradable polymer devices have been utilized as a means to deliver drugs in a controlled and less invasive manner. Poly (lactide-co-glycolide) (PLG) and poly (lactic acid) (PLA) microparticles such as double-wall/single-wall microspheres and microcapsules were heavily investigated for controlled delivery of small molecule drugs as well as proteins and DNA. The size distribution of protein-loaded biodegradable polymer microparticle is a crucial factor for allowable routes of administration. Also, the geometric structures of microparticles can influence the resulted release profile. In this project, by using the Precision Particle Fabrication method, we produced uniform double-wall microspheres (DWMS) with a protein-loaded (Bovine Serum Albumin) PLG core and a drug-free PLA shell, which was expected to provide better encapsulation of the protein as well as to postpone the protein release. Different inherent viscosity (i.v.) of PLG and PLA and different organic solvent configurations were used to produce uniform DWMS. Also, by studying the in vitro release profiles and microscopy images, we found that using ethyl acetate as shell-phase solvent, dichloromethane as core-phase solvent and using lower PLG and PLA i.v., better encapsulation of the protein-loaded core as well as clearly core-shell structure can be achieved. We have also successfully produced uniform protein-loaded DWMS with different shell thickness. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-12-07T15:11:37Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 3 XIA_Yujie.pdf: 3674210 bytes, checksum: 26bcc8ce9da33fb0afd9dcb7d161c735 (MD5) XIA_Yujie.docx: 9574692 bytes, checksum: 685b7bc96c1552a91ae9b9e4f903207d (MD5) XIA_Yujie.pdf: 3674210 bytes, checksum: 26bcc8ce9da33fb0afd9dcb7d161c735 (MD5) Made available in DSpace on 2012-02-01T00:54:27Z (GMT). No. of bitstreams: 3 Xia_Yujie.pdf: 3674020 bytes, checksum: 30eedd9b679b088ae5acc024c116e83b (MD5) license.txt: 4055 bytes, checksum: 3c0c6a19ba63792f144d8ad0bd36dd7e (MD5) XIA_Yujie.docx: 9574692 bytes, checksum: 685b7bc96c1552a91ae9b9e4f903207d (MD5) Item marked as restricted to the 'Administrator' Group (id=1) by William Ingram (wingram2@illinois.edu) on 2012-02-01T00:57:06Z Item is restricted until 2014-02-01T00:56:58Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:22Z Item was in collections: Dissertations and Theses - Chemical and Biomolecular Engineering (ID: 591) Graduate Theses and Dissertations at Illinois (ID: 204) No. of bitstreams: 4 Xia_Yujie.pdf.txt: 100846 bytes, checksum: 0ddf94066c21247fa6b535609b3f9618 (MD5) Xia_Yujie.pdf: 3674020 bytes, checksum: 30eedd9b679b088ae5acc024c116e83b (MD5) license.txt: 4055 bytes, checksum: 3c0c6a19ba63792f144d8ad0bd36dd7e (MD5) XIA_Yujie.docx: 9574692 bytes, checksum: 685b7bc96c1552a91ae9b9e4f903207d (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:22Z http://hdl.handle.net/2142/29537 en Copyright 2011 Yujie Xia Controlled release Drug delivery Poly (lactide-co-glycolide) Uniform double-wall microspheres Precision Particle Fabrication Uniform double wall microspheres/microcapsules for protein delivery Dissertation / Thesis text Chemical & Biomolecular Engr 1687 Chemical Engineering 0300 University of Illinois at Urbana-Champaign Thesis M.S. PHD:Chemical Engineering -UIUC 10KS0300PHD