2026-09-21T11:30:52Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/29549 2023-07-10 col_2142_11615 col_2142_5131 com_2142_9130 com_2142_8903 com_2142_5130

Kong, Hyun Joon Lai, Mei-Hsiu 2012-02-01T00:54:58Z 2014-02-01T11:00:33Z 2011-12 2012-02-01T00:54:58Z 2011-12 Nano-sized polymersomes functionalized with peptides are being increasingly studied for targeted delivery of diagnostic and therapeutic molecules. Earlier computational studies have suggested that ellipsoidal nanoparticles, compared to spherical ones, display enhanced binding efficiency with target cells, but this has not yet been experimentally validated. We hypothesized that hydrophilic polymer chains coupled to vesicle-forming polymers would result in ellipsoidal polymersomes. In addition, ellipsoidal polymersomes modified with cell adhesion peptides bind with target cells more actively than spherical ones. We examined this hypothesis by substituting polyaspartamide with octadecyl chains and varying numbers of poly(ethylene glycol) (PEG) chains. Increasing the degree of substitution of PEG from 0.5 to 1.0 wt% drove the polymer to self-assemble into an ellipsoidal polymersome with an aspect ratio of 2.1. Further modification of these ellipsoidal polymersomes with peptides containing an Arg-Gly-Asp sequence (RGD peptides) led to a significant increase in the rate of association and decrease in the rate of dissociation with a substrate coated with alphav-beta3 integrins. In addition, in a circulation-mimicking flow, the ellipsoidal polymersomes linked with RGD peptides adhered to target tissues more favorably than their spherical equivalents did. Overall, the results of this study will greatly serve to improve the efficiency of targeted delivery of a wide array of polymersomes loaded with various biomedical modalities. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2011-11-21T15:43:18Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Lai_Mei-Hsiu.pdf: 2003024 bytes, checksum: 8becd35995e81a0e4bed058cb3ba2e87 (MD5) Made available in DSpace on 2012-02-01T00:54:58Z (GMT). No. of bitstreams: 2 Lai_Mei-Hsiu.pdf: 2003042 bytes, checksum: 634992a599de67719f42a914fee54747 (MD5) license.txt: 4054 bytes, checksum: 6947c62a674998e778274e340ebd2e60 (MD5) Item marked as restricted to the 'Administrator' Group (id=1) by William Ingram (wingram2@illinois.edu) on 2012-02-01T00:57:08Z Item is restricted until 2014-02-01T00:56:58Z Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:33Z Item was in collections: Dissertations and Theses - Chemical and Biomolecular Engineering (ID: 591) Graduate Theses and Dissertations at Illinois (ID: 204) No. of bitstreams: 3 Lai_Mei-Hsiu.pdf.txt: 39391 bytes, checksum: 388895f95c06317e93b18785119fb3ec (MD5) Lai_Mei-Hsiu.pdf: 2003042 bytes, checksum: 634992a599de67719f42a914fee54747 (MD5) license.txt: 4054 bytes, checksum: 6947c62a674998e778274e340ebd2e60 (MD5) Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2014-02-01T11:00:33Z http://hdl.handle.net/2142/29549 en Copyright 2011 Mei-Hsiu Lai polymersomes Ellipsoidal polyaspartamide polymersomes with enhanced cell-targeting ability Dissertation / Thesis text Chemical & Biomolecular Engr 1687 Chemical Engineering 0300 University of Illinois at Urbana-Champaign Thesis M.S. PHD:Chemical Engineering -UIUC 10KS0300PHD