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oai:www.ideals.illinois.edu:2142/30944 2023-07-10 col_2142_5131 col_2142_16278 com_2142_5130 com_2142_16277 com_2142_9614

Wilund, Kenneth R. Cortez, Filand 2012-05-22T00:17:32Z 2012-05-22T00:17:32Z 2012-05 2012-05-22T00:17:32Z 2012-05 Visceral adipose tissue has been suggested to have a stronger association with disease than subcutaneous adipose tissue. This is primarily due to its inflammatory nature. Epicardial adipose tissue is a type of visceral fat located on the exterior of the heart. Recent evidence suggests an association between atherosclerosis, epicardial fat, and hepatic triglyceride deposition. PURPOSE -The purpose of this study was to determine the individual and combined effects of endurance exercise training and changes in dietary fat intake on myocardial triglyceride, a marker of epicardial fat, as well as hepatic triglycerides, another visceral fat depot implicated in CVD and diabetes risk, in a mouse model of dietary induced obesity. METHODS – Male c57BL/6 mice (n=73) fed a 45% high-fat diet for 6-weeks to induce obesity were randomly assigned into four groups: exercise high-fat, exercise low-fat, sedentary high-fat, sedentary low-fat. Exercise intervention consisted of treadmill running for 5 days/week, 40 min/day, at an intensity of 65-70% VO2 max for 12 weeks. After the 12 weeks, animals were sacrificed and both hearts and liver were removed. Using a triglyceride assay, myocardial and liver triglycerides levels were determined. RESULTS – Exercise training significantly lowered liver triglycerides in both high fat and low fat fed mice (p < 0.001 for both groups). However, dietary fat intake did not have a significant effect on liver triglycerides within activity groups. Exercise training also lowered myocardial triglycerides in mice fed a high fat diet (p = 0.005), but had no effect on myocardial triglycerides in mice fed a low fat diet. By contrast, mice fed a low fat diet had significantly lower myocardial triglycerides than high fat fed mice, regardless of activity group (p < 0.01 for both groups). CONCLUSION – Exercise training can attenuate epicardial/myocardial and hepatic fat accumulation in obese mice. Low fat diets can decrease myocardial fat accumulation in obese mice. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2012-04-16T15:04:38Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Cortez_Filand.pdf: 760375 bytes, checksum: d5cd8bfd8914856f8b37b581084e6aa9 (MD5) Made available in DSpace on 2012-05-22T00:17:32Z (GMT). No. of bitstreams: 2 Cortez_Filand.pdf: 759866 bytes, checksum: 06aeae0a020f254fb1a204abf40d44a2 (MD5) license.txt: 4065 bytes, checksum: 1dd02e5b4286c477260e9f517f33a004 (MD5) http://hdl.handle.net/2142/30944 en Copyright 2012 Filand Cortez Epicardial Fat Myocardial Triglycerides Exercise Individual and combined effects of exercise training and dietary fat on myocardial triglycerides in obese mice text Kinesiology & Community Health 1581 Kinesiology 0351 University of Illinois at Urbana-Champaign Thesis M.S. MS:Kinesiology -UIUC 10KS0351MS