2026-09-22T06:04:58Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/44759 2023-07-11 col_2142_5163 col_2142_5131 com_2142_5162 com_2142_234 com_2142_5130

Bhargava, Rohit Bhargava, Rohit Carney, Paul S. Do, Minh N. Ahuja, Narendra Reddy, Rohith 2013-05-28T19:18:36Z 2013-05-28T19:18:36Z 2015-05-28T10:01:02Z 2013-05 2013-05-28T19:18:36Z 2013-05 Fourier Transform Infrared (FT-IR) Spectroscopic Imaging is an optical technique that simultaneously provides morphological (two dimensional) and mid-infrared spectral (one dimensional) information for a specimen under observation. In this dissertation, we develop a new instrument that extends the capabilities of FT-IR imaging to provide three dimensional morphological information along with mid-infrared spectral information on the microscopic length scale. We first demonstrate that spectroscopic information from the mid-infrared can be used to perform histologic recognition and cancer detection in prostate, breast and skin cancer tissues. These studies utilize FT-IR imaging data of thin tissue slices from several hundred patients. The segmentation algorithms and instrumentation used are described in detail. We perform a rigorous analysis of instrumentation and data so as to understand the limits and limitations of current state-of-the-art instrumentation. We then propose a new instrument that adds a new dimension of information to current instruments and establish the new state-of-the-art in mid-infrared imaging. The theoretical basis of such instrumentation is presented in detail and techniques for visualization of four dimensional data are outlined. Item withdrawn by Alexis Thompson (athmpsn1@illinois.edu) on 2013-02-21T21:53:07Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Draft_thesis_8w.pdf: 42631683 bytes, checksum: 360f99c66ac2828c1b3f22bdcb7f998e (MD5) Made available in DSpace on 2013-05-28T19:18:36Z (GMT). No. of bitstreams: 2 Rohith_Reddy.pdf: 42629508 bytes, checksum: 8b431c6483381f8b5e91bfc26a3b8e4a (MD5) license.txt: 4062 bytes, checksum: b0c50edd2966f9135f5ce3bd13743c87 (MD5) Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (srobbins@illinois.edu) on 2013-05-28T19:21:31Z Item is restricted until 2015-05-28T19:21:22Z Restriction data tranferred 2014-07-01T11:16:35-05:00 Original Data Group with Access Administrator Release Date: 2015-05-28 14:21:22 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 44734 on 2015-05-28T10:01:02Z. http://hdl.handle.net/2142/44759 en Copyright 2013 Rohith Reddy Fourier Transform Infrared (FT-IR) spectroscopic Imaging Mid-Infrared Spectroscopic Tomography Spectroscopic Imaging Spectroscopic Tomography mid-Infrared (Mid-IR) Spectroscopy Imaging Mid infrared spectroscopic imaging and tomography text Bioengineering 1343 Bioengineering 0408 University of Illinois at Urbana-Champaign Dissertation Ph.D. PHD: Bioengineering-UIUC 10KS0408PHD