2026-09-21T23:09:35Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/46914 2023-07-11 col_2142_5131 col_2142_11615 com_2142_5130 com_2142_9130 com_2142_8903

Kong, Hyun Joon Choi, Je 2014-01-16T18:26:11Z 2014-01-16T18:26:11Z 2016-01-16T11:00:55Z 2013-12 2014-01-16T18:26:11Z 2013-12 In order to improve the targeting efficiency of polymersomes with a given number of targeting molecules conjugated, efforts are being made to control particle shape. I hypothesized that worm-shaped polymersomes formed from self-assembly between poly(amino acid)s would have more targeting capability than spherical polymersomes. Morphology of the resulting polymersome was observed afterwards. The polymersome was further modified to present Arg-Gly-Asp (RGD) motif, which is known to bind with cells that overexpress integrins. The binding affinities of the polymersomes onto target substrates were assessed using surface plasmon resonance (SPR) spectroscopy and adherence of the polymersomes to a target cell layer was also evaluated using flow chamber simulating blood flow. Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2013-12-10T23:11:05Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Choi_Je.pdf: 2242903 bytes, checksum: a8b90da270be48b03763f7c45a24c8f4 (MD5) Made available in DSpace on 2014-01-16T18:26:11Z (GMT). No. of bitstreams: 2 Je_Choi.pdf: 2243010 bytes, checksum: 60a1e9bca6ff2b3c9114ffec3e3820ee (MD5) license.txt: 4056 bytes, checksum: ad2a230f9754aaddde4a98dc99b7f800 (MD5) Restriction data tranferred 2014-07-01T11:36:48-05:00 Original Data Group with Access Administrator Release Date: 2016-01-16 12:27:27 UTC Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Item marked as restricted to the 'Administrator' Group (id=1) by Seth Robbins (robbins.sd@gmail.com) on 2014-01-16T18:27:36Z Item is restricted until 2016-01-16T18:27:27Z Limited Restriction Lifted for Item 46933 on 2016-01-16T11:00:55Z. http://hdl.handle.net/2142/46914 en Copyright 2013 Je Choi particle shape Worm-shaped polymersomes and their effects on targeting efficiency text Chemical & Biomolecular Engr 1687 Chemical Engineering 0300 University of Illinois at Urbana-Champaign Thesis M.S. MS:Chemical Engineering -UIUC 10KS0300MS