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Wesley, Susan Warwick 2014-12-14T07:04:10Z 2014-12-14T07:04:10Z 10000-01-01 1981 1981 34 aryl carbamates which were synthesized in the laboratory and 4 commercial carbamates, were screened for delayed neurotoxicity in the White Leghorn hen. Several carbamates proved to be delayed neurotoxins with this ability being particularly concentrated in the thiocarbamates bearing short, unbranched alkyl sidechains. The toxicity of these compounds was further examined in Musca domestica (LD(,50)) and Culex quinquefasciatus (LC(,50)) to discern correlations between esterase inhibition and delayed neurotoxicity. Various experiments were undertaken to determine a mode of action for carbamate delayed neurotoxins. These included electrophoresis of pertinent esterases and the examination of protective properties of these carbamates against a neurotoxic organophosphate. The phenomena of age and species specificity were also studied. The results of these experiments are equivocal, but they do not preclude the possibility that neurotoxic carbamates and organophosphates share a common site of action. Made available in DSpace on 2014-12-14T07:04:10Z (GMT). No. of bitstreams: 1 8127731.pdf: 5232966 bytes, checksum: e14938804b6b0dbfb4df19fff9a206b6 (MD5) Previous issue date: 1981 Embargo set by: Seth Robbins for item 68196 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 162 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1981. http://hdl.handle.net/2142/68018 (UMI)AAI8127731 eng Biology, Entomology The Delayed Neurotoxicity of Thio-, Allylthio- and Dithio-Carbamates and Its Relevance to a Mode of Action text Entomology Entomology University of Illinois at Urbana-Champaign Dissertation Ph.D.