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oai:www.ideals.illinois.edu:2142/69401 2023-07-11 col_2142_5131 col_2142_8888 com_2142_5130 com_2142_8887 com_2142_234

Novak, James Lawrence 2014-12-15T19:05:35Z 2014-12-15T19:05:35Z 10000-01-01 1988 1988 A technique has been developed in which a planar array of 32 microelectrodes, arranged in a 4 by 8 pattern with 200 $\mu$m separation, is used to record from and to stimulate the rat hippocampal slice preparation at multiple sites. Active suppression circuitry is used to prevent device saturation due to large stimulation artifacts. Control of media flow past the tissue is critical to observe signals and to preserve viability. The field potentials recorded are spatially unique and provide a two-dimensional description of the underlying population activity in the various pyramidal cell strata and subpopulations. The application of current source density analysis to the potential data permits accurate determination of peak times, in addition to the estimation of local current sources and sinks. Propagation delays of the compound action potential, first, and second population spikes along CAl calculated using these peak times are not uniform, and may indicate differences and directionality in coupling mechanisms. Made available in DSpace on 2014-12-15T19:05:35Z (GMT). No. of bitstreams: 1 8823217.pdf: 4577262 bytes, checksum: 1c91282a51874f1dab24a7d4d86f6f51 (MD5) Previous issue date: 1988 Embargo set by: Seth Robbins for item 69567 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 129 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1988. http://hdl.handle.net/2142/69401 (UMI)AAI8823217 Biology, Neuroscience Engineering, Biomedical Engineering, Electronics and Electrical Two-Dimensional Electrode Array Studies of Propagating Epileptiform Neural Activity in the Rat Hippocampal Slice text Electrical Engineering Electrical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.