2026-09-21T17:37:20Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/70067 2023-07-11 col_2142_5131 col_2142_14781 com_2142_5130 com_2142_687 com_2142_397

Becher, Michael Gordon 2014-12-15T21:09:56Z 2014-12-15T21:09:56Z 10000-01-01 1982 1982 The absorption and metabolism of fructose-arginine was examined in weanling rats. Fructose-arginine is the Amadori compound resulting when dextrose reacts with arginine during the Maillard reaction. Fructose-(U-('14)C)-arginine and L-(U-('14)C)-arginine were administered by stomach intubation. Samples of urine, feces and CO(,2) were taken at various time intervals up to 72 hours. The absorption of the Maillard compound was found to be much slower than that of the free arginine. The percentage of administered radioactivity was much lower in expired CO(,2) for the fructose-arginine and fecal radioactivity was greater than that seen for the arginine. High levels of antibiotics in the diet had little effect on the absorption of arginine except that diarrhea led to increased fecal output. The effect of antibiotic pretreatment on the absorption of fructose-arginine was dramatic. The expiration of ('14)CO(,2) never reached a maximum during 72 hours. Less than 50% of the ('14)CO(,2) expired by the non-antibiotic-fed controls was seen in the pretreated animals. Urine radioactivity did not reach a maximum until 72 hours, as compared to a 32 hour maximum in the controls. Mutagenicity testing was conducted on Maillard products using the Ames mutagenicity test. Twenty-one amino acids were individually heated with dextrose and these reaction mixtures were tested with Salmonella typhimurium strains TA 98, TA 100 and TA 1537 with and without S-9 activation. No apparent mutagenicity was observed. The same results were shown for mixtures of amino acids and dextrose and solvent-extracted fractions of leucine and isoleucine Maillard mixtures. The only positive mutagenic results occurred when high concentration Maillard reaction mixtures were tested. Positive mutagenic responses were seen for mixtures resulting from a 1 M glycine and 1 M dextrose solution or a 1 M lysine and 1 M dextrose solution. Made available in DSpace on 2014-12-15T21:09:56Z (GMT). No. of bitstreams: 1 8218427.pdf: 2959038 bytes, checksum: ca6143dd273976a3aa79b15ed6ece405 (MD5) Previous issue date: 1982 Embargo set by: Seth Robbins for item 70233 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 94 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1982. http://hdl.handle.net/2142/70067 (UMI)AAI8218427 Agriculture, Food Science and Technology Studies on the Synthesis and Metabolism of 1-(l-Arginine)-1-Deoxy-D-Fructose and the Possible Mutagenic Effects of Maillard Reaction Mixtures text Food Science Food Science University of Illinois at Urbana-Champaign Dissertation Ph.D.