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Mahler, George Stephen 2014-12-15T23:18:51Z 2014-12-15T23:18:51Z 10000-01-01 1986 1986 Chiral stationary phases derived from N-3,5-dinitrobenzoyl amino acids, amides of 1-aryl-1-alkylamines and N-2-naphthyl amino acids have proven to be viable sorbents for the direct liquid chromatographic separation of enantiomers. In an effort to extend the utility of these chrial stationary phases, a variety of analytical methodologies involving straightforward derivatization of commonly encountered compound types of practical interest have been developed. Protocols for the liquid chromatographic separation of the enantiomers of chiral heterocyclic amines, secondary alcohols, vicinal diols, and cyclopropyl amino acids are presented and their applications, limitations, and potentials are discussed. The suitability of these methodologies for analytical as well as preparative separations are discussed. The use of N-3,5-dinitrobenzoyl-R-phenylglycine as a classical resolving agent for the resolution of several amines by formation of diastereomeric salts of differing solubilities is also considered. Made available in DSpace on 2014-12-15T23:18:51Z (GMT). No. of bitstreams: 1 8701556.pdf: 4739763 bytes, checksum: ff38f034bf815c053c8acc6887c2c707 (MD5) Previous issue date: 1986 Embargo set by: Seth Robbins for item 70516 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 174 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1986. http://hdl.handle.net/2142/70350 (UMI)AAI8701556 Chemistry, Organic Methods Development in Chiral Chromatography text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.