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Bass, Vivian Dee 2014-12-16T06:35:26Z 2014-12-16T06:35:26Z 10000-01-01 1983 1983 The absorption, distribution and excretion of oxytetracycline and tetracycline were studied in female beagles following intra-arterial and oral drug administration. Concentrations of drug in body fluids and selected tissues were determined by high performance liquid chromatography utilizing an internal standard. The average biologic half-life of oxytetracycline was 6.4 hours, whereas that of tetracycline was 13.7 hours following intra-arterial administration (10 mg/kg body weight). The half-life of tetracycline was decreased to 8.2 hours when a lower dose (5 mg/kg body weight) was administered. Oxytetracycline and tetracycline were rapidly but incompletely absorbed when administered to canines per os. Both antibiotics had similar absorption (< 0.5 hr) and elimination (4.8-6.6 hrs) half-lives. Comparisons of the recovery of both drugs in urine following intra-arterial and oral drug administration revealed that tetracycline had a higher bioavailability (35.9%) than that determined for oxytetracycline (10.7%). Following intra-arterial administration of oxytetracycline (10 mg/kg body weight) the highest concentration of drug was present in the kidney, followed by the liver, heart, muscle, and lung in declining order of concentration. A positive correlation was demonstrated between coexistent mean plasma and tissue concentrations for the tissues examined. Made available in DSpace on 2014-12-16T06:35:26Z (GMT). No. of bitstreams: 1 8309909.pdf: 5236636 bytes, checksum: baefec997d4ce991347b1f0ba30075d5 (MD5) Previous issue date: 1983 Embargo set by: Seth Robbins for item 71467 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 153 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983. http://hdl.handle.net/2142/71301 (UMI)AAI8309909 Health Sciences, Pharmacology Absorption, Distribution and Excretion of Oxytetracycline and Tetracycline in Female Beagles text Veterinary Medical Science Veterinary Medical Science University of Illinois at Urbana-Champaign Dissertation Ph.D.