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Smith, Bradford Bixby 2014-12-16T06:35:34Z 2014-12-16T06:35:34Z 10000-01-01 1983 1983 Previous studies have implicated E. coli endotoxins in the pathogenesis of insufficient milk production in the periparturient sow. Experiment I demonstrated that E. coli endotoxins (4, 8, or 16 mg 055:B5 strain) given subcutaneously to 150-170 kg sows on day 2 postpartum (PP + 2) decreased plasma prolactin (PRL) concentrations to 25-35% of pre-endotoxin concentrations within 4 hours. Piglet weight, an indirect indicator of milk production, declined significantly concomitant with the decline in PRL. Experiment II demonstrated that 8mg endotoxin suppressed PRL and piglet growth when administered on PP + 2 but not when given on PP + 6 for the first or second time. Endotoxin administration suppressed thyrotropin releasing hormone (TRH) (100 (mu)g IV) stimulated PRL release on PP + 2 but not on PP + 6. The results suggested that the suppressive effects of E. coli endotoxins on PRL are partially mediated directly at the adenohypophysis. Experiment III demonstrated that the dopamine vesicle depleting agent, reserpine (0.025 mg/kg), and the DA receptor blocking agents, haloperidol (10 mg/sow) and chlorpromazine (0.5 mg/kg), were ineffective in elevating PRL concentrations when given on PP + 5 or PP + 6. TRH (500 (mu)g IM) elevated PRL for 20-30 minutes. These results suggested that PRL is not under chronic inhibitory control by the hypothalamus as observed in other species. Experiment IV demonstrated that PRL concentrations did not increase following electric shock stimulation or restraint and venipuncture but did decline following removal of the suckling stimulus. Results obtained in this thesis suggest that low concentrations of E. coli endotoxins exert a suppressive effect on milk production by suppressing PRL release and may be a significant factor in the pathogenesis of lactation failure in the periparturient sow. Made available in DSpace on 2014-12-16T06:35:34Z (GMT). No. of bitstreams: 1 8410048.pdf: 7616936 bytes, checksum: 71fc5d7deb3f0292e151c6d4f0794afb (MD5) Previous issue date: 1983 Embargo set by: Seth Robbins for item 71479 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 229 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983. http://hdl.handle.net/2142/71313 (UMI)AAI8410048 Agriculture, Animal Pathology The Role of Escherichia Coli Endotoxins in The Pathogenesis of Lactation Failure in The Sow text Dissertation Ph.D. Veterinary Medical Science Veterinary Medical Science University of Illinois at Urbana-Champaign