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oai:www.ideals.illinois.edu:2142/71343 2023-07-11 col_2142_5131 col_2142_16405 com_2142_5130 com_2142_16404 com_2142_14833

10000-01-01 1987 1987 Three groups of swine (6 per group) were used to assess alterations in blood flow induced by single doses of T-2 toxin infused into the pulmonary artery. Two groups were dosed at 0.6 or 2.4 mg/kg T-2 toxin and the third group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hour (predosing) and at 90 minute intervals for 6 hours, using the radiolabeled microsphere technique. Hemodynamic parameters were obtained at the same time points. Lundeen, Gregg Richard 2014-12-16T06:35:48Z 2014-12-16T06:35:48Z The infusion of T-2 toxin resulted in reductions in cardiac output (CO). This trend appeared to reverse itself in the low dose group after 3 hours, whereas in the high dose group, CO continued to decline. Alterations in mean arterial pressure (MAP) paralleled the reduction observed in CO. A compensatory tachycardia was observed in response to the reduced CO and MAP. Renal, pancreatic and splenic blood flows were the most severely compromised by T-2. Blood flow to the brain and heart also decreased but to a lesser degree. In contrast, adrenal, hepatic and gastrointestinal blood flow increased following toxin administration. The effects of T-2 toxin on systemic and regional blood flow have not been previously described. It was the goal of this study to characterize the functional alterations comprising this shock syndrome with regard to blood flow. These findings indicate that T-2 toxicosis involves a complex interaction of multiple organ systems. The animals observed in this study exhibited classic signs of circulatory shock which included hypotension, tissue hypoperfusion and reduced cardiac output. The alterations in organ/tissue blood flow observed in this study may help previously reported effects of T-2 toxin on various physiologic and pathologic parameters. Made available in DSpace on 2014-12-16T06:35:48Z (GMT). No. of bitstreams: 1 8711831.pdf: 4677751 bytes, checksum: fa5ad95c91adefcea1e7e789511e2748 (MD5) Previous issue date: 1987 Embargo set by: Seth Robbins for item 71509 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 146 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1987. http://hdl.handle.net/2142/71343 (UMI)AAI8711831 Biology, Veterinary Science Systemic and Regional Distribution of Blood Flow During T-2 Toxin Induced Shock in Swine (Microspheres) text Veterinary Medical Science Veterinary Medical Science University of Illinois at Urbana-Champaign Dissertation Ph.D.