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oai:www.ideals.illinois.edu:2142/71425 2023-07-11 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

Cooper, Kimbal Edward 2014-12-16T06:45:43Z 2014-12-16T06:45:43Z 10000-01-01 1983 1983 The purpose of this thesis is to review and extend the theory of ion transport through membrane channel. A review of previous theory is presented which includes both Nernst-Planck and Eyring Rate theory approaches. The predictions and assumptions of the two theories are discussed and a unified derivation of both from a more fundamental stochastic theory is presented. That more fundamental stochastic theory is based on the Langevin equation. A simulation technique based on this equation is presented. The technique called Brownian dynamics is then used to study ion transport through membrane channels. Four cases are considered: (1) no ion-ion interaction, no channel structure; (2) no ion-ion interaction, channel structure present; (3) ion-ion interaction, no channel structure; (4) ion-ion interaction, channel structure present. A detailed discussion of the simulation is given with an indication of possible future improvements. The Brownian dynamic approach illustrates nicely the shortcomings of the Nernst-Planck and Eyring theory approaches. Made available in DSpace on 2014-12-16T06:45:43Z (GMT). No. of bitstreams: 1 8409899.pdf: 3824878 bytes, checksum: 54f1cccfba80eb58d5ddc325eada2953 (MD5) Previous issue date: 1983 Embargo set by: Seth Robbins for item 71591 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 220 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1983. http://hdl.handle.net/2142/71425 (UMI)AAI8409899 Biology, Animal Physiology A Brownian Dynamics Analysis of Ion Movement in Membrane Channels text Physiology and Biophysics Physiology University of Illinois at Urbana-Champaign Dissertation Ph.D.