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Schaeffer, David J. Johnson, Larry Richard 2014-12-17T23:22:42Z 2014-12-17T23:22:42Z 10000-01-01 1992 1992 The acute toxicity of TNT, 2-amino,-4,6-dinitrotoluene (2A) and 4-amino,-2,6-dinitrotoluene (4A) to Photobacterium phosphoreum (Microtox reagent), Daphnia magna (daphnia), and Dugesia dorotocephala (planaria) was enhanced by near-ultraviolet light (nUV) coexposure. The light enhanced toxicity of TNT, 2A and 4A must be considered to fully evaluate the environmental hazards of these compounds. The 2A and 4A metabolites of TNT were toxic at environmentally relevant concentrations and their production during biological degradation of TNT related waste must be considered. Binary mixtures of TNT, 2A or 4A demonstrated a more than additive toxicity towards the Microtox reagent with nUV coexposure. 2A and 4A also proved to be developmental toxicants towards the planarian at very low concentrations and this developmental toxicity was further enhanced by nUV coexposure. The planarian, but not the daphnid, can metabolize TNT to 2A and 4A, as can plants, mammals and microorganisms. The production of 2A and 4A by activated sludge digestion and/or other biota in the environment must be considered since these metabolites can be more toxic than TNT. Female rats can more effectively metabolize TNT than males and the observation of cancer only in female rats could be the result of a sex specific difference in TNT metabolism. An environmental risk assessment for TNT must include consideration of sunlight coexposure, the species exposed, exposure concentrations of TNT and metabolites and toxicological endpoints including lethality, and developmental toxicity. Made available in DSpace on 2014-12-17T23:22:42Z (GMT). No. of bitstreams: 1 9305569.pdf: 6469153 bytes, checksum: dca3fcaa67708159874b8643c8ec8033 (MD5) Previous issue date: 1992 Embargo set by: Seth Robbins for item 72723 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 159 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1992. http://hdl.handle.net/2142/72555 (UMI)AAI9305569 Biology, Ecology Health Sciences, Toxicology Environmental Sciences Light Enhanced Toxic/tumorigenic Potential of Trinitrotoluene (Tnt) and Analogs text Ph.D. Veterinary Medical Science Veterinary Medical Science University of Illinois at Urbana-Champaign Dissertation