2026-09-21T22:41:50Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/72983 2023-07-11 col_2142_5131 col_2142_16508 com_2142_5130 com_2142_16507 com_2142_14793 com_2142_8903

Oldfield, Eric Oldfield, Eric Nair, Satish K. Gennis, Robert B. Gruebele, Martin Guerra, Francisco 2015-01-21T19:55:22Z 2015-01-21T19:55:22Z 2017-01-22T10:15:43Z 2014-12 2015-01-21 2014-12 The broad, long-term objective of this research is to develop drug leads for new antibiotics, antiparasitics, and cancer chemotherapeutics. Two main areas of focus are inhibition of the Methyl Erythritol Phosphate (MEP; non-mevalonate pathway) pathway in bacterial and parasitic human pathogens and inhibition of isoprenoid synthases in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, and inhibition of the essential penultimate and ultimate enzymes of the MEP pathway, IspG (iron sulfur protein G; also known as GcpE and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate synthase) and IspH (also know as LytB and E-4-hydroxy-2-C-methyl-erythritol pyrophosphate reductase), respectively. Investigation of novel cancer drugs focuses on mono- and combination therapies targeting the farnesyl pyrophosphate synthase (FPPS) and GGPPS (geranyl geranyl pyrophosphate synthase) enzymes with drugs that interact with several pathways involved in autophagy and apoptosis. Item withdrawn by Laura Spradlin (lspradl2@illinois.edu) on 2014-11-05T16:59:30Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Guerra_Francisco.pdf: 12742644 bytes, checksum: 48013933e9862c1faa0ca4d047835d8e (MD5) Made available in DSpace on 2015-01-21T19:55:22Z (GMT). No. of bitstreams: 1 Francisco_Guerra.pdf: 12742816 bytes, checksum: de028541ec21789fc8e376a16cb85458 (MD5) Embargo set by: Seth Robbins for item 73172 Lift date: 2017-01-21T19:56:18Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 73172 on 2017-01-22T10:15:43Z. http://hdl.handle.net/2142/72983 en Copyright 2014 Francisco Guerra isoprenoid iron-sulfur proteins 4Fe-4S bisphosphonate diphosphate Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors text School of Molecular & Cell Bio 1415 Biophysics & Computnl Biology 0319 University of Illinois at Urbana-Champaign Dissertation Ph.D. PHD:Biophys&Computnl Bio -UIUC 10KS0319PHD