2026-09-18T19:10:52Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/73084 2023-07-11 col_2142_5131 col_2142_8888 com_2142_5130 com_2142_8887 com_2142_234

Boppart, Stephen A. Bower, Andrew 2015-01-21T19:59:15Z 2015-01-21T19:59:15Z 2017-01-22T10:15:37Z 2014-12 2015-01-21 2014-12 In recent years, many noninvasive, high-resolution biomedical optical imaging techniques based on unique, yet complementary, contrast mechanisms have emerged. While each imaging modality is able to elucidate certain properties of the particular sample under study, an integrated approach in which all modalities are acquired in a simultaneous, co-registered manner can prove advantageous in obtaining a more complete understanding of the sample under study. While this multimodal approach to biomedical imaging is beginning to find more widespread use, thus far most applications of these techniques have been purely qualitative, ignoring the incredibly dense, multidimensional datasets acquired. This thesis presents the framework and several applications of a quantitative model-based combinatorial analysis method. The analysis technique developed provides a direct link between multimodal image contrast and physiological biomarkers. Applications include identification of tissue constituents in fixed tissue slices and classification of cell death mechanisms in a living engineered tissue sample. Item withdrawn by Mark Zulauf (zulauf@illinois.edu) on 2014-12-04T14:59:32Z Item was in collections: University of Illinois Theses & Dissertations (ID: 1) No. of bitstreams: 1 Bower_Andrew.pdf: 9255219 bytes, checksum: 21068aaa77365fbaae719b2c78033286 (MD5) Made available in DSpace on 2015-01-21T19:59:15Z (GMT). No. of bitstreams: 1 Andrew_Bower.pdf: 9255219 bytes, checksum: 21068aaa77365fbaae719b2c78033286 (MD5) Embargo set by: Seth Robbins for item 73273 Lift date: 2017-01-21T19:59:39Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 73273 on 2017-01-22T10:15:37Z. http://hdl.handle.net/2142/73084 en Copyright 2014 Andrew Bower Multimodal Microscopy Multiphoton Imaging Image Analysis Model-based quantitative combinatorial optical microscopy for extracting clinical imaging biomarkers text Electrical & Computer Eng 1933 Electrical & Computer Engr 1200 University of Illinois at Urbana-Champaign Thesis M.S. MS:Electr & Computer Eng-UIUC 10KS1200MS