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Khan, Muhammad Ibrahim 2015-07-22T22:33:15Z 2015-07-22T22:33:15Z 2017-07-23T09:15:33Z 2015-05 2015-04-13 Optical sensing techniques are being employed in widespread applications ranging from aerospace to electronics, process control and medicine. Optical biosensors are desirable in various clinical applications for their greater sensitivity, electrical passivity, wide dynamic range and high spatial resolution. Optical biosensors such as laser interferometers and optical fiber sensors can be incorporated for the real time measurement of biofluid parameters. Various applications in medicine such as blood monitoring in hemodialysis require the monitoring of multiple biofluid parameters. As multiple monitors are needed for sensing, the sensor becomes bulky and costly. Miniature optical sensors based on elastomers are best suited for this purpose. Sensors based on deformable elastomeric materials have several benefits such as greater sensitivity, high spatial resolution, reliability and low cost. The Multifunctional Elastomeric Grating Sensor (EGS) presented in this thesis is fabricated using elastomeric materials. The EGS is made by integrating a two-dimensional (2D) diffraction grating inside a hemispherical chamber. The sensing mechanism of the EGS is based on the diffraction of light. The laser beam passing through the 2D grating and the fluid inside the chamber is diffracted. The diffraction angle and the power of diffraction orders are used to compute the biofluid parameters. This sensor can be used for real time monitoring of glucose concentration, refractive index, pressure and opacity of the fluid. In future, the EGS will also be useful in highly sensitive temperature measurements. This device is being tested for more advanced biological experiments such as DNA hybridization and enzyme-linked immunosorbent assay (ELISA). This simple, compact and low cost device has an enormous potential for future use in various clinical applications such as blood monitoring in hemodialysis. Submission published under a 24 month embargo labeled 'U of I only', the embargo will last until 2017-05-01 The student, Muhammad Khan, accepted the attached license on 2015-04-12 at 18:13. The student, Muhammad Khan, submitted this Thesis for approval on 2015-04-12 at 18:22. This Thesis was approved for publication on 2015-04-13 at 13:28. DSpace SAF Submission Ingestion Package generated from Vireo submission #7823 on 2015-07-22 at 14:17:41 Made available in DSpace on 2015-07-22T22:33:15Z (GMT). No. of bitstreams: 2 KHAN-THESIS-2015.pdf: 1573808 bytes, checksum: 59491f5f3be1d287b7f75eb34da247cc (MD5) LICENSE.txt: 4210 bytes, checksum: d89eed34639161f181d085cdaef4b874 (MD5) Previous issue date: 2015-04-13 Embargo set by: Seth Robbins for item 79848 Lift date: 2017-07-22T22:34:16Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD system U of I Only Restriction Lifted for Item 79848 on 2017-07-23T09:15:33Z. application/pdf http://hdl.handle.net/2142/78607 en Copyright 2015 Muhammad Ibrahim Khan Elastomeric grating sensor Biofluid sensing Elastomeric grating sensor for multifunctional optofluidic biosensing text text 2015-5 Electrical & Computer Eng Electrical & Computer Engr University of Illinois at Urbana-Champaign Thesis M.S.