2026-09-19T14:40:01Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/78763 2023-07-11 col_2142_5131 com_2142_5130

2015-07-22T22:45:44Z Rodriguez-Zas, Sandra L. Rodriguez-Zas, Sandra L. Caetano-Anollés, Gustavo Chen, Xiaohui Kelley, Keith W. Nixon, Scott Evan 2015-07-22T22:45:44Z 2017-07-23T09:15:27Z 2015-05 2015-04-23 In the mouse model of Bacillus Calmette-Guérin (BCG)-induced inflammation, focus is placed upon phenotypic and gene-expression responses to the original challenge. Studies of the phenotypic response to BCG involves several behavior indicators, categorized as representing an initial period of sickness response, and a set of depression-like behaviors that can endure for several weeks. Little is known about the impact of relationships among indicators on these studies, as most analyses have treated indicators independently. Gene-expression studies have also been small in scale, limiting what is known about gene-expression during these behavioral changes. With the availability of Next-Generation Sequencing platforms, the scale of transcriptome analysis can be greatly increased. This study aims to address these previous limitations, characterizing behavioral and gene-expression responses to BCG-induced inflammation. Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2017-05-01 The student, Scott Nixon, accepted the attached license on 2015-04-21 at 11:27. The student, Scott Nixon, submitted this Dissertation for approval on 2015-04-21 at 15:53. This Dissertation was approved for publication on 2015-04-23 at 09:47. DSpace SAF Submission Ingestion Package generated from Vireo submission #7977 on 2015-07-22 at 14:25:57 Made available in DSpace on 2015-07-22T22:45:44Z (GMT). No. of bitstreams: 5 NIXON-DISSERTATION-2015.pdf: 2512806 bytes, checksum: 82fb16ab56bf5a6c2bc5f55016f84973 (MD5) senixon_thesis_TableofContents_apr202015.docx: 26108 bytes, checksum: 11b15cabdf3ed3cfa1b901e7f80eac75 (MD5) senixon_thesis_body_apr202015.docx: 2558998 bytes, checksum: 3721988a565fee5077e48b544b3ec760 (MD5) senixon_thesis_title_apr132015.docx: 14002 bytes, checksum: 496025e14ebd54dcc6a8dc05688669a6 (MD5) LICENSE.txt: 4208 bytes, checksum: 277a1896081b816eba459233383e7fbd (MD5) Previous issue date: 2015-04-23 Embargo set by: Seth Robbins for item 80004 Lift date: 2017-07-22T22:46:21Z Reason: Author requested closed access (OA after 2yrs) in Vireo ETD system Limited Restriction Lifted for Item 80004 on 2017-07-23T09:15:27Z. application/pdf http://hdl.handle.net/2142/78763 en Copyright 2015 Scott Nixon Behavior Transcriptome Functional Analysis Study of phenotypic and gene expression response to bacterial challenge text text 2015-5 Graduate College Programs Informatics University of Illinois at Urbana-Champaign Dissertation Ph.D.