2026-09-23T11:42:19Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/80576 2023-07-11 col_2142_5131 col_2142_8859 com_2142_5130 com_2142_8858 com_2142_234

Gratton, Enrico Colyer, Ryan Anthony 2015-09-25T20:03:08Z 2015-09-25T20:03:08Z 10000-01-01 2008 2008 This new hardware was used to observe the conformational dynamics of a calmodulin sample labeled with a FRET pair, and encapsulated within 100nm lipid vesicles. A toolbox of analysis techniques was developed for PTA, and was used to quantitatively describe the transitions and fluctuations of the conformation of calmodulin. Analysis was done in a model-free manner, and also by applying known parameters about the system to extract more specific information. Using the information obtained, a conformational model was developed to describe the dynamic behavior of calmodulin's conformation in terms of its binding with calcium. In addition, measurements conducted in the presence of a peptide derived from Ca2+/calmodulin-dependent protein kinase II were used to examine the properties of calmodulin's conformational dynamics while interacting with its binding targets. Made available in DSpace on 2015-09-25T20:03:08Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3337743.pdf: 1294506 bytes, checksum: 626853ab02a00eb1aeb46a754d8bb4af (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 81858 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 94 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/80576 (MiAaPQ)AAI3337743 eng Biophysics, General Development of a Fluorescence Lifetime Based Method to Detect and Analyze Single Molecule Reactions in Solution text Physics Physics University of Illinois at Urbana-Champaign Dissertation Ph.D.