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Gold, Paul E. Pych, Jason Clifford 2015-09-25T20:39:10Z 2015-09-25T20:39:10Z 10000-01-01 2005 2005 The present series of experiments evaluated the hypothesis that cholinergic activity regulates multiple memory systems. The hypotheses specifically tested were: (a) cholinergic activity in the hippocampus regulates place learning, (b) cholinergic activity in the striatum regulates response learning and (c) cholinergic activity in one structure regulates competitive interactions with the other. To this end, rats were tested in tasks in which acquisition of either place or response information led to the correct solution. In Chapter 2, rats were treated with intrastriatal glucose (glucose is hypothesized to upregulate cholinergic functioning) injections just prior to learning. In Chapters 3 and 4, acetylcholine release was measured in the hippocampus and striatum just prior to and during learning. The results, in general, support the hypothesis that increases in cholinergic activity in the hippocampus and striatum facilitate acquisition of place and response information, respectively, and that cholinergic activity in one structure can regulate competitive interactions with the other. Made available in DSpace on 2015-09-25T20:39:10Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3199118.pdf: 2440158 bytes, checksum: 7cd52f112275643c07f0239eeabbe96a (MD5) Previous issue date: 2005 Embargo set by: Seth Robbins for item 83377 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 133 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005. http://hdl.handle.net/2142/82096 (MiAaPQ)AAI3199118 eng Biology, Neuroscience Acetylcholine Regulation of the Hippocampus and Striatum During Learning text Psychology Psychology University of Illinois at Urbana-Champaign Dissertation Ph.D.