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Pack, Daniel W. Forrest, Marcus Laird 2015-09-25T20:43:16Z 2015-09-25T20:43:16Z 10000-01-01 2003 2003 Finally, for polymeric devices to be made safe and efficient for in vivo usage there must be some means to target them to specific cells or tissues. Various cyclodextrins were conjugated to PEI using an amide linkage. The hydrophobic interior of the cyclodextrin allows the facile addition of small targeting and lysomotropic agents to the polyplex without chemical conjugation. By applying a hydrophobic analog of human insulin to the cyclodextrin polyplexes, I was able demonstrate a 2--3 fold enhancement in transfection efficiency in insulin receptor-rich cell lines. Made available in DSpace on 2015-09-25T20:43:16Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3101840.pdf: 6385399 bytes, checksum: 48f8464ed3a6a738108dc7a1988bd0f8 (MD5) Previous issue date: 2003 Embargo set by: Seth Robbins for item 83633 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 150 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003. http://hdl.handle.net/2142/82352 (MiAaPQ)AAI3101840 eng Engineering, Biomedical Engineering of Nonviral Vectors for Gene Therapy text Chemical and Biomolecular Engineering Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.