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Kenis, Paul J.A. Choban, Eric Raymond 2015-09-25T20:43:22Z 2015-09-25T20:43:22Z 10000-01-01 2004 2004 Similarly in this thesis, multistream laminar flow is used in microfluidic systems for (1) biocatalytic synthesis of fine chemicals by microscale-enabled efficient regeneration of cofactors, as well as for (2) the study of intestinal stem cells on a surface that mimics their in vivo environment. In the first system, the ability to focus reagent streams close to the electrode wall results in a cofactor regeneration efficiency of over 30%. In the second system, microfluidic networks are used to create covalently immobilized surface gradients of extracellular matrix (ECM) proteins, laminin and collagen 1. These microfluidic platforms are capable of eliciting cell responses such as migration, proliferation, and differentiation, and offer the possibility of in vitro studies of a variety cell lines in response to different immobilized and soluble ECM components. Made available in DSpace on 2015-09-25T20:43:22Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3160874.pdf: 7101085 bytes, checksum: fb3a37348162951824188973c160e2f6 (MD5) Previous issue date: 2004 Embargo set by: Seth Robbins for item 83650 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 158 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. http://hdl.handle.net/2142/82369 (MiAaPQ)AAI3160874 eng Engineering, Chemical Laminar Flow-Based Microchemical Systems for Power Generation, Electrochemical Synthesis, and Biological Cell Studies text Chemical and Biomolecular Engineering Chemical and Biomolecular Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.