2026-09-22T16:36:39Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/82392 2023-07-11 col_2142_5131 col_2142_11615 com_2142_5130 com_2142_9130 com_2142_8903

Pack, Daniel W. Ramsey, Joshua 2015-09-25T20:43:29Z 2015-09-25T20:43:29Z 10000-01-01 2006 2006 While the hybrid vectors have combined some of the beneficial traits of the polymer and viral components the efficiency of the vector is low, in comparison to conventional viral vectors. Based on the changes in gene expression over time and the effect of chloroquine, the limiting step of hybrid vector cell transduction appears to be endolysosomal escape of the complex. The polymer component fails to mediate escape as efficiently as the MLV envelope protein, likely resulting in the degradation of internalized hybrid vector complexes. Incorporation of polymers better suited for mediating escape from the endolysosomal network could likely improve the hybrid vector efficiency. Made available in DSpace on 2015-09-25T20:43:29Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3250313.pdf: 4299832 bytes, checksum: 2b06e07c4a233f5a3dbceaaab7b9ac9b (MD5) Previous issue date: 2006 Embargo set by: Seth Robbins for item 83673 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 171 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. http://hdl.handle.net/2142/82392 (MiAaPQ)AAI3250313 eng Engineering, Chemical Hybrid Gene Therapy Vectors Comprised of Synthetic Polymer and Noninfectious Virus -Like Particles text Chemical Engineering Chemical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.