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Leckband, Deborah E. Lee, Keng Jin 2015-09-25T20:43:38Z 2015-09-25T20:43:38Z 10000-01-01 2008 2008 Finally, fluorescence imaging assessed cadherin clustering and actin organization in E-cadherin expressing cells cultured on E-, N-, and C-cadherin ectodomains. As expected, the formation of filamentous actin correlated with the Rac activation amplitudes in E-cadherin expressing cells. The results also showed that lateral cadherin clustering, which is thought to be an initial response to cadherin ligation, occurs in E-cadherin expressing cells as a result of both heterophilic and homophilic binding. However, I also showed that lateral cadherin clustering is not a cadherin-specific response. These results are important because they suggest that cadherin-dependent differences in intracellular signaling may play a greater role in cell sorting than the biophysical properties of bonds between ectodomain subtypes. Made available in DSpace on 2015-09-25T20:43:38Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3337841.pdf: 1543682 bytes, checksum: f47d0e7cb9f4d36f7009ae0328125d03 (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 83694 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 121 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/82413 (MiAaPQ)AAI3337841 eng Engineering, Chemical Regulation of Homophilic and Heterophilic Adhesion Among Classical Cadherins text Chemical Engineering Chemical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.