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oai:www.ideals.illinois.edu:2142/82471 2023-07-11 col_2142_5131 col_2142_11615 com_2142_5130 com_2142_9130 com_2142_8903

McHugh, Anthony J. Brodbeck, Kevin J. 2015-09-25T20:44:15Z 2015-09-25T20:44:15Z 10000-01-01 1999 1999 Protein burst on injection was entirely eliminated when the protein particle was densified with stearic acid and placed in a slow phase-inverting depot formulation. Particle densification can potentially be used with any protein or highly soluble drug agent, unlike other techniques that are protein specific. Taking advantage of the effects of low aqueous affinity and densification, a PLGA solution depot was produced that sustained serum hGH levels in normal rats at 10 to 200 ng/mL for 28 days. Made available in DSpace on 2015-09-25T20:44:15Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9952973.pdf: 5187882 bytes, checksum: fcf9979bbf4b49f6e121f8651e1faa67 (MD5) Previous issue date: 1999 Embargo set by: Seth Robbins for item 83752 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 147 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999. http://hdl.handle.net/2142/82471 (MiAaPQ)AAI9952973 eng Health Sciences, Pharmacy Phase Inversion Dynamics of Polylactic Glycolic Acid Solutions Related to Biopharmaceutical Drug Delivery text Chemical Engineering Chemical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.