2026-09-22T13:07:57Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/82525 2023-07-11 col_2142_5131 col_2142_13007 com_2142_5130 com_2142_13006

Stephanie Ceman Ozawa, Rie 2015-09-25T20:45:40Z 2015-09-25T20:45:40Z 10000-01-01 2008 2008 The X chromosome-linked form of Kallmann syndrome (KS) is caused by disruption of the Kal-1 gene, which encodes a secreted protein called Anosmin-1. The definitive features of the KS phenotype are anosmia and hypogonadism. Despite high conservation of the Kal-1 gene from invertebrates to vertebrates, the Kal-1 homolog in mice has not been identified. The unavailability of an animal model has hampered research on the disease in vivo. Hence, little is known about the cellular processes and molecular functions underlying KS. Here, I isolated a Drosophila kal-1 null mutant, which removes the entire kal-1 coding region. Antibody staining shows that Anosmin-1 specifically localizes to the dendrites of olfactory receptor neurons (ORNs) throughout development. The dendrites of ORNs sense odorants in the environment including the Drosophila melanogaster male-specific pheromone 11-cis-vaccenyl acetate, which is known to inhibit male-male mating behaviors. Interestingly, mutant males that lack kal-1 function inappropriately court other males. These results imply a possible role of kal-1 in mating behaviors in part by mediating pheromone perception. Made available in DSpace on 2015-09-25T20:45:40Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3347493.pdf: 1193572 bytes, checksum: 13b9e717b6f66c86db320f18a2a975c0 (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 83806 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 92 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/82525 (MiAaPQ)AAI3347493 eng Biology, Neuroscience Specific Roles of Kal-1 in Olfaction: A Model of Kallmann Syndrome in Drosophila text Neuroscience Neuroscience University of Illinois at Urbana-Champaign Dissertation Ph.D.