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oai:www.ideals.illinois.edu:2142/82543 2023-07-11 col_2142_5131 col_2142_13007 com_2142_5130 com_2142_13006

Greenough, William T. Irwin, Scott Alan 2015-09-25T20:45:47Z 2015-09-25T20:45:47Z 10000-01-01 2000 2000 The discovery that proteins are synthesized at synapses, away from somata where most proteins are made, is fairly recent, and only a couple of proteins are currently known to be made near synapses; none have been shown to be made in response to changes in the synaptic environment. Proteins made in response to afferent activity at synapses are likely candidates to be involved with the plasticity (functional, structural, or both) of synapses, as afferent activation is largely responsible for the postnatal organization of the nervous system. In attempts to discern which proteins are made at synapses specifically for involvement in synaptic plasticity, it was discovered that fmr -1 mRNA, a product of the FMR-1 gene, associates rapidly with protein synthesis machinery in response to neurotransmitter stimulation in an in vitro synaptoneurosome preparation. This suggested that the Fragile-X Mental Retardation Protein, the product of fmr-1 mRNA, is synthesized at synapses in response to afferent activation and is possibly involved in synaptic plasticity. The following studies attempt to further link the expression/function of this protein with synaptic plasticity processes. Made available in DSpace on 2015-09-25T20:45:47Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9971102.pdf: 7655242 bytes, checksum: df9577235ee05e8098ede8b94798e04b (MD5) Previous issue date: 2000 Embargo set by: Seth Robbins for item 83824 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 156 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2000. http://hdl.handle.net/2142/82543 (MiAaPQ)AAI9971102 eng Health Sciences, Human Development Elucidating the Role of the Fragile-X Mental Retardation Protein in the Central Nervous System text Neuroscience Neuroscience University of Illinois at Urbana-Champaign Dissertation Ph.D.