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oai:www.ideals.illinois.edu:2142/82850 2023-07-11 col_2142_5131 col_2142_13836 com_2142_5130 com_2142_13835 com_2142_234

Gerard Wong Slimmer, Scott Collins 2015-09-25T20:53:19Z 2015-09-25T20:53:19Z 10000-01-01 2009 2009 This research also details the first attempt to obtain useful information from heterogeneous DNA sequencing data. A sample of the selection population from each of the twelve rounds of in vitro selection was heterogeneously sequenced without any prior separation or purification. The observed concurrence of qualitative changes in the heterogeneous sequencing chromatograms with observed changes in the catalytic activity of the population is evidence of the ability of heterogeneous DNA sequencing to successfully monitor the evolution of DNA populations during in vitro selection. The ability to successfully analyze heterogeneous DNA samples containing multiple DNA sequences using a single sequencing experiment may play an important role in driving the development of new DNA sequencing technologies and shaping the future of genomic research. Made available in DSpace on 2015-09-25T20:53:19Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3363093.pdf: 2426460 bytes, checksum: ecf79e84c4f215a7a5de1c40179d889f (MD5) Previous issue date: 2009 Embargo set by: Seth Robbins for item 84131 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 121 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009. http://hdl.handle.net/2142/82850 (MiAaPQ)AAI3363093 eng Biology, Bioinformatics In Vitro Selection and Characterization of Catalytic DNA in Model Biological Systems text Materials Science and Engineering Materials Science and Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.