2026-09-21T06:03:54Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/83850 2023-07-11 col_2142_5131 col_2142_14787 com_2142_5130 com_2142_9630 com_2142_234

Beck, Carolyn Lin, Hui-Hung 2015-09-25T21:12:27Z 2015-09-25T21:12:27Z 10000-01-01 2006 2006 To address these shortcomings, this dissertation proposes the use of piecewise-linear multivariable models of the effects of anesthetic and stimuli inputs on patient vital signs. These models are developed by utilizing data-based system identification methods. Different model structures such as linear time invariant (LTI), piecewise linear switching and parameter-varying, are investigated and verified. Robust gain scheduled controllers are constructed and simulated using a linear parameter varying (LPV) framework. The use of multivariable state-space models for patient modeling is novel in this research area, as is the proposed use of piecewise-linear models. The modeling results indicate that the proposed piecewise-linear models yield improved simulation responses over traditional PK-PD models, in comparisons made with respect to single-output effects. Further, individual models may provide reasonable central models in the sense that simulated output responses obtained by applying the input data set for one volunteer to the piecewise-linear models for other volunteers produces an acceptable fit to the output data for the first volunteer. Similar results are found for our constructed individual controllers when applied as a generic controller for other volunteer data. Made available in DSpace on 2015-09-25T21:12:27Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3223655.pdf: 4156567 bytes, checksum: e8d8bd79c7accdc815733286818f3e19 (MD5) Previous issue date: 2006 Embargo set by: Seth Robbins for item 85131 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 170 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. http://hdl.handle.net/2142/83850 (MiAaPQ)AAI3223655 eng Health Sciences, Medicine and Surgery Multivariable Modeling and Control of the Response to Anesthesia text Mechanical Engineering Mechanical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.