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Saif, M. Taher A. Yang, Shengyuan 2015-09-25T21:12:37Z 2015-09-25T21:12:37Z 10000-01-01 2007 2007 Both the one- and two-component force sensors have been used to study the mechanobiological response of fibroblasts, endothelial cells, and neurons. The major findings of the studies include: The force response of monkey kidney fibroblasts is strongly linear, reversible and repeatable under large deformations, with a small stiffening at the initial deformation stage; Actin filaments play a dominant role in taking the cellular internal forces; Mechanical indentation/compression may induce actin agglomeration inside the cell, which supplies a perfect example of cellular mechanotransduction; The in vivo stretch force response of Drosophila axons is linear, and there is a rest tension in the axons and they maintain this rest tension; Tension in the axons is required for normal synaptic function, and muscle twitches may be involved in tuning this tension. Made available in DSpace on 2015-09-25T21:12:37Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3290440.pdf: 3712246 bytes, checksum: 7bf2e575c629cab9f8e1895abe8b70eb (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 85174 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 106 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/83893 (MiAaPQ)AAI3290440 eng Biophysics, General Micromachined Sensors and Their Applications in the Study of Mechanical Response of Single Living Cells text Mechanical Engineering Mechanical Engineering University of Illinois at Urbana-Champaign Dissertation Ph.D.