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oai:www.ideals.illinois.edu:2142/84076 2023-07-11 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

Rinehart, Kenneth L., Jr. Costerison, Jennifer Riggs 2015-09-25T22:12:44Z 2015-09-25T22:12:44Z 10000-01-01 2002 2002 The present study is an investigation of different synthetic routes to the natural product utilizing several protecting group strategies. Extensive studies were required to gain insight into the susceptibility of the intermediates to reaction conditions. This work has led to the first synthetic route to the intermediate microcystin-LR-di-Boc-guanidine which can be converted to a constitutional isomer of microcystin-LR. Mass spectral analysis and HPLC retention time show the presence of microcystin-LR although a clean 1H NMR could not be obtained. Made available in DSpace on 2015-09-25T22:12:44Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3070284.pdf: 5537667 bytes, checksum: f321ae1bcf16bd1b241f87a7ecc10105 (MD5) Previous issue date: 2002 Embargo set by: Seth Robbins for item 85357 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 155 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2002. http://hdl.handle.net/2142/84076 (MiAaPQ)AAI3070284 eng Chemistry, Organic An Approach to the Total Synthesis of the Protein Phosphatase 1 and 2A Inhibitor Microcystin -Lr text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.