2026-09-22T15:19:00Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/84121 2023-07-11 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

Kenneth S. Suslick Wang, Jiangyun 2015-09-25T22:13:02Z 2015-09-25T22:13:02Z 10000-01-01 2003 2003 "We have developed an interesting hypothesis for Olfactory Receptor (OR) mechanism. We are so sensitive to thiols and amines that the most natural way to explain this is that OR is a metalloprotein. We have found a consensus sequence ""HXXCE"" in the 4--5 loop of ORs, which not only binds strongly to Cu2+ and Zn2+, but also turns alpha helical after metal binding. Since the 4--5 loop is as hydrophobic as the fourth helix of OR, charge neutralization of metal ion increases its hydrophobicity, thus it might turn into transmembrane helix and replace the fourth helix. Endogenous ligand binding to the metal site might disturb the charge balance and triggers helix motion, which results in a cell signaling cascade, and eventually the sense of smell." Made available in DSpace on 2015-09-25T22:13:02Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3101990.pdf: 6652140 bytes, checksum: 17ca79785a06a149204dffcb9ca66973 (MD5) Previous issue date: 2003 Embargo set by: Seth Robbins for item 85402 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 191 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003. http://hdl.handle.net/2142/84121 (MiAaPQ)AAI3101990 eng Chemistry, Biochemistry De Novo Heme Protein Design text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.