2026-09-23T07:43:51Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/84147 2023-07-11 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

Katzenellenbogen, John A. Collins, Margaret Lynn 2015-09-25T22:13:11Z 2015-09-25T22:13:11Z 10000-01-01 2004 2004 Key hydrophobic and hydrogen bonding moieties were incorporated onto a variety of core scaffolds including amphipathic benzene, bicyclo[2.2.2]octane, and urea, resulting in three different series of compounds that could be utilized as coactivator binding inhibitors (CBIs). A fluorescence-based assay was used to evaluate the ability of the CBIs to effectively block the ER-coactivator interaction. The most effective compounds synthesized were amphipathic benzene derivatives with Ki's of 7 and 4 muM, which are the best in vitro affinities to date in our research group. Made available in DSpace on 2015-09-25T22:13:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3153275.pdf: 10321881 bytes, checksum: 5baf254bad6489ea2681baa39e014f13 (MD5) Previous issue date: 2004 Embargo set by: Seth Robbins for item 85428 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 120 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2004. http://hdl.handle.net/2142/84147 (MiAaPQ)AAI3153275 eng Health Sciences, Oncology Design and Synthesis of Estrogen Receptor Coactivator Binding Inhibitors text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.