2026-09-24T23:15:05Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/84195 2023-07-11 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

2015-09-25T22:13:25Z 10000-01-01 2005 2005 "This work further extends initial studies into using FTMS to examine NRP/PK synthetases and provides the most detailed insights into pyochelin, yersiniabactin and FK520 biosynthesis achieved to date. This study also represents the first observation of multiple covalently modified active site peptides in parallel using robust digestion protocols. It is hoped that further refinement of this mass spectrometry-based platform will bolster NRP/PK reengineering efforts towards the design of ""unnatural"" natural products that combat modern antibiotic-resistant pathogens." Kelleher, Neil L. McLoughlin, Shaun Michael 2015-09-25T22:13:25Z Made available in DSpace on 2015-09-25T22:13:25Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3199084.pdf: 5955396 bytes, checksum: 3526f353a061cf0eaa55c6d7971dc483 (MD5) Previous issue date: 2005 Embargo set by: Seth Robbins for item 85476 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 190 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005. http://hdl.handle.net/2142/84195 (MiAaPQ)AAI3199084 eng Chemistry, Biochemistry Mass Spectrometry and Thiotemplate Assembly: Unique Insights Into the Production of Natural Products on >100 kDa Enzymes text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.