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Oldfield, Eric Sanders, John 2015-09-25T22:13:27Z 2015-09-25T22:13:27Z 10000-01-01 2005 2005 A number of bisphosphonates are currently used to treat human bone resorption disorders. In recent years, these compounds have been shown to have additional biological properties, such as the ability to inhibit the growth of parasite cells and the ability to stimulate human gammadelta T cells. We have used computational techniques, such as CoMSIA and pharmacophore modeling, together with experimental data, to explain these secondary activities. In addition, this work has led to the discovery of new, highly-potent bisphosphonates, which could be useful in the treatment of human bone resorption diseases, parasitic diseases, and in the immunotherapeutic treatment of some diseases, such as cancer. Made available in DSpace on 2015-09-25T22:13:27Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3199132.pdf: 4841624 bytes, checksum: 5cecec7ba4ccfe6ed1403fe785d9f6ce (MD5) Previous issue date: 2005 Embargo set by: Seth Robbins for item 85482 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 194 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005. http://hdl.handle.net/2142/84201 (MiAaPQ)AAI3199132 eng Chemistry, Pharmaceutical An Improved Understanding of Bisphosphonates Through Computational Techniques text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.