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Kelleher, Neil L. Roth, Michael 2015-09-25T22:13:46Z 2015-09-25T22:13:46Z 10000-01-01 2007 2007 Top Down MS analysis of proteins from human cervical carcinoma cell lines and primary human leukocytes harvested from leukoreduction filters provided identification of 261 protein forms, with ∼12% overlap between the two proteomes. The protein forms were produced by 162 unique genes (∼22% overlap). The above information demonstrates the dynamic expression patterns of proteins in various human cell types. Among the above identifications, 89 proteolysis events, 16 methylation events, 10 phosphorylation sites, 7 acetylations (non-N-terminal), and 9 other modifications were observed. These data indicate the significant post-translational complexity present in the human proteome and validate the application of Top Down in complex proteomes, with the most precise molecular characterization of human proteins demonstrated to date. Made available in DSpace on 2015-09-25T22:13:46Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3290364.pdf: 4843164 bytes, checksum: dce47bc198f256aad58fbfca94dceb9d (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 85561 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 116 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/84280 (MiAaPQ)AAI3290364 eng Chemistry, Analytical Novel Applications of Top Down MS/MS for Interrogating the Human Proteome text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.