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Hergenrother, Paul J. Meyer, Stephen Todd 2015-09-25T22:14:03Z 2015-09-25T22:14:03Z 10000-01-01 2009 2009 Hairpin loops occur in a region of RNA that doubles back on itself, leaving several unpaired bases at the terminus of a duplexed region. Dimers of 2-deoxystreptamine are known to bind to this class of secondary structure. Certain functionalized napthyridines are also known to display the appropriate donor-acceptor relationship to have a selective hydrogen bonding interaction with guanine. An effort was undertaken to combine these two disparate types of binding to enhance the overall selectivity of the ligand. The resulting compounds extended the methodology for binding to hairpin loops, and expanded the available repertoire for the chemistry of naphthyridines. Made available in DSpace on 2015-09-25T22:14:03Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3392218.pdf: 1887470 bytes, checksum: b176a30fa2416be9fbb8765555e2cf8c (MD5) Previous issue date: 2009 Embargo set by: Seth Robbins for item 85628 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 152 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009. http://hdl.handle.net/2142/84347 (MiAaPQ)AAI3392218 eng Chemistry, Organic Selective Targeting of RNA With Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.