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oai:www.ideals.illinois.edu:2142/84367 2023-07-11 col_2142_5131 col_2142_14789 com_2142_5130 com_2142_14788 com_2142_8903

Wang, Andrew H.J. Lian, Chenyang 2015-09-25T22:14:10Z 2015-09-25T22:14:10Z 10000-01-01 1997 1997 The anthracycline daunorubicin has been widely used to treat acute leukemia clinically. The newly designed bisanthracycline bisintercalator WP631 has shown promising results against the anthracycline resistance that is due to the transport proteins, e.g., P-glycoprotein. The 3D structures of 1:1 WP631/d(CGTACG)$\sb2$ and 1:1 WP631/d(CGJACG)$\sb2$ showed that the aglycone rings intercalate slightly shallower than those in the 2:1 DAU/d(CGTACG)$\sb2$ and the daunosamine moieties are elevated from the minor groove floor, which would explain why the binding constant of WP631 to DNA is 3 orders less than expected. WP631 has also shown tight binding to modified DNA d(CGJACG)$\sb2.$ The 3D structures of these two complexes have pointed the direction for the future design of bisanthracycline drugs. Made available in DSpace on 2015-09-25T22:14:10Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9737178.pdf: 7283684 bytes, checksum: 8a572b599ba9e22a27b13436602da495 (MD5) Previous issue date: 1997 Embargo set by: Seth Robbins for item 85648 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 158 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997. http://hdl.handle.net/2142/84367 (MiAaPQ)AAI9737178 eng Biology, Molecular Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy text Chemistry Chemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.