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oai:www.ideals.illinois.edu:2142/84774 2023-07-11 col_2142_5131 col_2142_14795 com_2142_5130 com_2142_14794 com_2142_14793 com_2142_8903

Glaser, Michael Wanaski, Stephen Philip 2015-09-25T22:27:50Z 2015-09-25T22:27:50Z 10000-01-01 2001 2001 Components of the mitogen activated protein kinase (MAPK) signaling cascade also localized into domains in vesicles containing acidic lipids. The formation of lateral membrane domains induced by Ki-Ras 4B and the Raf-cysteine rich domain (Raf-CRD) was inhibited by the anti-tumor agent farnesylthiosalicylic acid (FTS). The inhibition of Ras membrane domains by farnesylthiosalisylic acid was proposed to inhibit Ras function and the results provided a model of how the membrane organizes and regulates the MAP kinase signaling cascade. Made available in DSpace on 2015-09-25T22:27:50Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3017244.pdf: 7288458 bytes, checksum: a1c692ffe0717d0903136fdba22873b0 (MD5) Previous issue date: 2001 Embargo set by: Seth Robbins for item 86055 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 194 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2001. http://hdl.handle.net/2142/84774 (MiAaPQ)AAI3017244 eng Chemistry, Biochemistry Lateral Membrane Domains Organize and Regulate Components of Signal Transduction Pathways text Biochemistry Biochemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.