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oai:www.ideals.illinois.edu:2142/84849 2023-07-11 col_2142_5131 col_2142_14795 com_2142_5130 com_2142_14794 com_2142_14793 com_2142_8903

Glaser, Michael Thu, Thant Si 2015-09-25T22:28:11Z 2015-09-25T22:28:11Z 10000-01-01 2007 2007 In addition to steroid hormones, signaling by platelet-derived growth factor (PDGF)-A in peripheral myelination was investigated. Lower levels of P0 were found in the developing sciatic nerve of PDGF-A null transgenic mice, especially when active myelin synthesis occurs. Morphological deformities of the myelin sheath were also observed in the sciatic nerve of the null mice. Furthermore, cocultures established with DRG neurons and Schwann cells from the null mice showed decreased expression of myelin basic protein (MBP) transcripts. PDGF-A null Schwann cells differentiating into the myelinating phenotype without neurons expressed lower levels of MBP and 3beta-hydroxysteroid dehydrogenase mRNAs and produced less progesterone and its metabolites. Treatment of the differentiating Schwann cells with PDGF-A increased the expression of MBP and the production of progesterone and its metabolites. Together, these results shed light on the importance of steroid hormones, growth factors, and their interaction in the process of myelin synthesis in the peripheral nervous system. Made available in DSpace on 2015-09-25T22:28:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3301235.pdf: 4574288 bytes, checksum: 25d4dd4adfb1a40833e99e58acbbf98d (MD5) Previous issue date: 2007 Embargo set by: Seth Robbins for item 86130 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 159 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2007. http://hdl.handle.net/2142/84849 (MiAaPQ)AAI3301235 eng Biology, Molecular Steroid Hormone and Growth Factor Regulation of Peripheral Myelination text Biochemistry Biochemistry University of Illinois at Urbana-Champaign Dissertation Ph.D.