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Cooke, Paul S. Helferich, William G. Du, Mengyuan 2015-09-25T22:31:08Z 2015-09-25T22:31:08Z 10000-01-01 2009 2009 In the first study, we demonstrated that low dose dietary genistein negated the inhibitory effect of tamoxifen on mammary tumor growth. Although high dose genistein did not show the same effect, high tumor prevalence was observed. In the second study, dietary genistein was shown to promote breast cancer metastasis to lungs in athymic mice. The results from these studies suggest that the consumption of dietary supplements containing genistein may not be safe to breast cancer survivors. In our third study, we evaluated three metastasis models using different injection sites. We have successfully developed animal models that can produce a proper level of distant metastasis. These preclinical animal models will allow us to conduct further research to investigate the impact of soy isoflavones on breast cancer metastasis in the future. Made available in DSpace on 2015-09-25T22:31:08Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3362775.pdf: 1301935 bytes, checksum: c58285ac8590802310fb0c97c24fd2aa (MD5) Previous issue date: 2009 Embargo set by: Seth Robbins for item 86242 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 103 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009. http://hdl.handle.net/2142/84961 (MiAaPQ)AAI3362775 eng Health Sciences, Nutrition The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis text Nutritional Sciences Nutritional Sciences University of Illinois at Urbana-Champaign Dissertation Ph.D.