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John W. Erdman, Jr. Boileau, Amy Christine 2015-09-25T22:31:12Z 2015-09-25T22:31:12Z 10000-01-01 1999 1999 Lycopene is the predominant carotenoid in tomatoes and tomato-based foods and is also a predominant carotenoid in human serum and tissues. The observation that serum and tissue lycopene is more than 50% cis-lycopene, whereas tomatoes and tomato-based foods contain mainly all-trans lycopene, has led to the hypothesis that cis-isomers of lycopene are more bioavailable. When bile acid micelles were prepared in vitro from crystalline lycopene, cis-isomers of lycopene were significantly enriched in the optically-clear micelle preparation. Mesenteric lymph duct cannulated ferrets were used to study the in vivo absorption of lycopene. Following an oral dose, lymph was collected for 2 hours. The lymph secretions contained a significantly greater proportion of cis-lycopene than any other fraction (P < 0.01). These studies demonstrate that in ferrets, cis-isomers of lycopene are more bioavailable than the all-trans isomer. Made available in DSpace on 2015-09-25T22:31:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9952968.pdf: 7081266 bytes, checksum: 14c94b078b5313ff9fb896e38ea4fcb4 (MD5) Previous issue date: 1999 Embargo set by: Seth Robbins for item 86265 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 132 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999. http://hdl.handle.net/2142/84984 (MiAaPQ)AAI9952968 eng Health Sciences, Public Health Intestinal Uptake of Carotenoids: Implications for Carotenoid Bioavailability text Nutritional Sciences Nutritional Sciences University of Illinois at Urbana-Champaign Dissertation Ph.D.