2026-09-18T22:59:00Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/84987 2023-07-11 col_2142_5131 col_2142_14797 com_2142_5130 com_2142_14796 com_2142_397

1999 Donovan, Sharon M. Park, Yoo Kyoung 2015-09-25T22:31:13Z 2015-09-25T22:31:13Z 10000-01-01 1999 Our final study investigated the mechanism(s) by which IGF-I up-regulates LPH activity. The three treatment groups were: 100% TPN, 20% PEN with or without 1.0 mg/kg IGF-I. IGF-I increased LPH activity and LPH activity per unit mature LPH ∼2-fold over PEN alone, but did not affect LPH mRNA or the relative abundance of proLPHh or mature LPH. Fractional and absolute synthesis rates of mucosal protein and LPH were similar among the treatment groups. Total mucosal protein synthesis was increased 60% in the IGF-I treated animals. Based on these data, we speculate that the mechanism by which IGF-I up-regulates LPH is post-translational, either via reducing LPH degradation or specifically altering LPH enzyme kinetics. Made available in DSpace on 2015-09-25T22:31:13Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9953105.pdf: 8567266 bytes, checksum: f121865676ac4327c84cd7d8633edbdb (MD5) Previous issue date: 1999 Embargo set by: Seth Robbins for item 86268 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 182 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999. http://hdl.handle.net/2142/84987 (MiAaPQ)AAI9953105 eng Agriculture, Animal Culture and Nutrition Orally Administered IGF -I Combined With Partial Enteral Nutrition Alters Intestinal Morphology and Disaccharidase Activity During Parenteral Nutrition in Neonatal Piglets text Nutritional Sciences Nutritional Sciences University of Illinois at Urbana-Champaign Dissertation Ph.D.