2026-09-20T03:25:35Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/85455 2023-07-11 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

Nair, Satish K. Yu, John-Paul Jaewoon 2015-09-25T22:46:09Z 2015-09-25T22:46:09Z 10000-01-01 2006 2006 The lantibiotic nisin is a 34-residue bacteriocin produced by the Gram-positive bacteria Lactococcus lactis spp. It is first ribosomally synthesized as an inactive precursor which is then post-translationally modified into its mature biologically active form. Described herein is a two-part study investigating (1) the structural basis of how the characteristic nisin lanthionine rings are installed by the enzyme NisC and (2) how Lactococcus lactis spp., despite producing an effective bacteriocin like nisin, is resistant to the toxic effects of nisin. The results described here together provide the first structural insights into the biosynthesis of nisin as well as insights into how L. lactis demonstrates autoimmunity to the lantibiotic nisin. Made available in DSpace on 2015-09-25T22:46:09Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3223758.pdf: 3737524 bytes, checksum: e31d0001dae62cbd4041ae9fefd8e91b (MD5) Previous issue date: 2006 Embargo set by: Seth Robbins for item 86736 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 128 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. http://hdl.handle.net/2142/85455 (MiAaPQ)AAI3223758 eng Biophysics, General Structural and Biochemical Studies of Nisin *Biosynthesis and Autoimmunity text Biophysics and Computational Biology Biophysics and Computational Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.