2026-09-22T12:14:51Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/85467 2023-07-11 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

Oldfield, Eric Hudock, Michael 2015-09-25T22:46:11Z 2015-09-25T22:46:11Z 10000-01-01 2008 2008 Cancer and infectious diseases represent huge health threats to societies around the globe. Bisphosphonate drugs, long known for their ability to treat bone resorption diseases, have also served as the template for designing new agents against a variety of other diseases. In this work, computational modeling methods have been applied to design the newest series of bisphosphonate molecules optimized for additional targets relating to parasitic diseases, bacterial cell wall biosynthesis, and cancer. These modeling efforts have not only resulted in more potent inhibitors, but have also increased our understanding of these disease targets, which include T. cruzi hexokinase, farnesyl diphosphate synthase, undecaprenyl diphosphate synthase, and geranylgeranyl diphosphate synthase. Made available in DSpace on 2015-09-25T22:46:11Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3314794.pdf: 2787308 bytes, checksum: 7d02ef63160c34e3b969240f00ecc760 (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 86748 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 188 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/85467 (MiAaPQ)AAI3314794 eng Chemistry, Pharmaceutical Elucidating Targets for Infectious Diseases and Cancer: A Computational Approach text Biophysics and Computational Biology Biophysics and Computational Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.