2026-09-23T00:39:23Z https://www.ideals.illinois.edu/oai-pmh

oai:www.ideals.illinois.edu:2142/85470 2023-07-11 col_2142_5131 col_2142_14828 com_2142_5130 com_2142_14827 com_2142_14793 com_2142_8903

2015-09-25T22:46:12Z 10000-01-01 2008 2008 Oldfield, Eric Cao, Rong 2015-09-25T22:46:12Z Bisphosphonates are a class of drugs widely used to treat bone resorption diseases. Recently, bisphosphonates have been found to have anti-cancer, anti-parasitic, anti-bacterial and herbicidal activity. They also have the unexpected property of activating human gammadelta T cells to kill tumor cells. In this work, I used experimental, mainly x-ray crystallography and computational methods to understand the structure activity relationships of these bisphosphonates with their targets, farnesyl diphosphate synthase, geranylgeranyl diphosphate synthase, and undecaprenyl diphosphate synthase. New bisphosphonates have been developed and optimized based on these findings. In particular, new lipophilic bisphosphonates targeting multiple prenyl-transferases are developed and far more potent than current commercially available bisphosphonate drugs in tumor cell killing, and gammadelta T cell activation. Made available in DSpace on 2015-09-25T22:46:12Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3337715.pdf: 2724603 bytes, checksum: 00143008892fdac7c230b8f83a49e9e1 (MD5) Previous issue date: 2008 Embargo set by: Seth Robbins for item 86751 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 180 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2008. http://hdl.handle.net/2142/85470 (MiAaPQ)AAI3337715 eng Health Sciences, Oncology Experimental and Computational Study of Bisphosphonates Targeting Isoprenoid Biosynthesis Pathway text Biophysics and Computational Biology Biophysics and Computational Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.