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Richard L. Magin Oh, Deborah Kyung 2015-09-25T22:46:15Z 2015-09-25T22:46:15Z 10000-01-01 1999 1999 A tissue uptake model was developed to describe the fluorescein dermofluorometer signal in terms of the local blood flow and capillary permeability. The fluorescein signal is characterized by a wash-in time constant dependent on both the blood flow and permeability. Under flow-limited conditions the wash-in time constant is inversely proportional to the blood flow only. Significant differences in the fluorescein wash-in time constant were measured between diabetic and non-diabetic subjects (p < 0.10) and between diabetic patients with chronic foot ulcers and those without ulcers (p < 0.01). A new technique, dual dye dermofluorometry, which measures the simultaneous signals from an intravascular tracer, indocyanine green, and a diffusible tracer, sodium fluorescein, was developed. The indocyanine green signal is described by a physiologically-based pharmacokinetic model with a wash-in time constant inversely proportional to the blood flow. The extravascular fluorescein signal is extracted from the observed signal by subtracting a scaled version of the indocyanine green signal. Indocyanine green wash-in time constants were significantly different between patients whose foot ulcers led to amputation relative to those whose foot ulcers healed without surgery (p < 0.10) and between patients with past foot ulcers relative to patients with no history of foot ulcers (p < 0.05). It was determined that while the flow-limited assumption for fluorescein was valid in healthy rat skin, it was not valid in diabetic subjects. Made available in DSpace on 2015-09-25T22:46:15Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9944955.pdf: 6505218 bytes, checksum: a282b89b471ed53cab4e09f179367a0d (MD5) Previous issue date: 1999 Embargo set by: Seth Robbins for item 86772 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 157 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999. http://hdl.handle.net/2142/85491 (MiAaPQ)AAI9944955 eng Engineering, Biomedical In Vivo Fluorometric Assessment of the Skin Microcirculation text Biophysics and Computational Biology Biophysics and Computational Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.