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oai:www.ideals.illinois.edu:2142/86304 2023-07-11 col_2142_5131 col_2142_14855 com_2142_5130 com_2142_14854 com_2142_14793 com_2142_8903

Tzumin Lee Zheng, Xiaoyan 2015-09-28T15:03:16Z 2015-09-28T15:03:16Z 10000-01-01 2005 2005 The intermingling of larval functional neurons with adult-specific neurons during metamorphosis contributes to the development of the Drosophila adult brain. This study provides evidence for cell-autonomous involvement of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons throughout the entire nervous system. Loss of Babo/dSmad2 drastically delays adult-specific neurons' initial morphogenesis, while Babo/dSmad2 acts to assure timely expression of EcR-B1 in larval functional neurons. This study, thus, suggests that TGF-beta signaling prior to metamorphosis may be widely required to prepare neurons for the rapidly changing environment present during metamorphosis. Given that many vertebrate TGF-beta signaling molecules are dynamically present in the postnatal brain, it is possible that similar mechanisms may help modulate neural circuitry in higher organisms during periods of extensive morphogenesis. Made available in DSpace on 2015-09-28T15:03:16Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3202199.pdf: 2013861 bytes, checksum: ca63b3cf1df6a22778709fa7fd97eb26 (MD5) Previous issue date: 2005 Embargo set by: Seth Robbins for item 87585 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 94 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2005. http://hdl.handle.net/2142/86304 (MiAaPQ)AAI3202199 eng Biology, Genetics Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain text Cell and Developmental Biology Cell and Developmental Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.