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oai:www.ideals.illinois.edu:2142/86308 2023-07-11 col_2142_5131 col_2142_14855 com_2142_5130 com_2142_14854 com_2142_14793 com_2142_8903

Jonathan Joseph Henry Elkins, Matthew Brian 2015-09-28T15:03:17Z 2015-09-28T15:03:17Z 10000-01-01 2006 2006 One clone was isolated from the cDNA library on the basis of its embryonic expression pattern and its sequence similarity to human NRBP and mouse MADM genes. This gene, xMADML, was characterized through molecular analysis, which showed both similarity and important differences to MADM, and protein knock-down, which showed that xMADML is necessary in both the developing retina and lens. Analysis of the expression patterns of known genes in the xMADML-knockdown background showed that expression of some genes, particularly Pax6, were altered, whereas the expression patterns of other genes were not. This suggests that xMADML is involved in the signaling cascades necessary to control retina and lens development. Further understanding of the genetic controls of eye development will allow for increased understanding of the general process of development. Made available in DSpace on 2015-09-28T15:03:17Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3250236.pdf: 4591424 bytes, checksum: 190270930c70c5b555f034d9b030fb53 (MD5) Previous issue date: 2006 Embargo set by: Seth Robbins for item 87589 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs U of I Only 152 p. Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2006. http://hdl.handle.net/2142/86308 (MiAaPQ)AAI3250236 eng Biology, Cell Isolation and Characterization of a Novel Gene, xMADML, Involved in Xenopus Laevis Eye Development Using Cornea -Lens Regeneration text Cell and Developmental Biology Cell and Developmental Biology University of Illinois at Urbana-Champaign Dissertation Ph.D.